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Recent Webinars

Integrating functional modeling to enhance clinical variant interpretation

Dr. Bob Nussbaum (Chief Medical Officer, Invitae); Dr. Britt Johnson (Medical Director, Metabolic Genetics and Immunology. Medical Affairs Director, Biopharma Partnerships, Invitae)
April 29, 2020
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The program, intended for genetic counselors, geneticists, and other healthcare providers (in the EMEA time zone), will help learners to:

1. Define the limitations of existing approaches to address variants of uncertain significance in variant interpretation
2. Evaluate the validity and clinical application of robust, quantitative, and scalable functional modeling approaches to variant classification


Functional modeling: The next frontier in variant interpretation

Keith Nykamp, PhD, Invitae; Douglas M. Fowler, PhD, University of Washington School of Medicine; Carlos Araya, PhD, Invitae
April 09, 2020
View Recording

Join us as we discuss the challenges of variants of uncertain significance (VUS) in the clinical setting and demonstrate the role of functional modeling in addressing some of these challenges. This in-depth presentation will provide insight for both those who watched our previous functional modeling webinar as well as anyone new to the subject.

The webinar will help you:
1. Understand how often to expect VUS results and the traditional approaches to VUS resolution
2. Describe the role of functional modeling as an additional evidence type that can assist in variant classification
3. Define different functional approaches and their application to specific variant types


Integrating functional modeling to enhance clinical variant interpretation

Robert L. Nussbaum, MD, Chief Medical Officer, Invitae; Swaroop Aradhya, PhD, FACMG, Head of Global Medical Affairs, Invitae
April 02, 2020
View Recording

The program, intended for genetic counselors, geneticists, and other healthcare providers (in the Asia-Pacific time zones) interested in variant classification, will help learners:

1. Define the limitations of existing approaches to address variants of uncertain significance in variant interpretation
2. Evaluate the validity and clinical application of robust, quantitative, and scalable functional modeling approaches to variant classification


Invitae Boosted Exome: Providing affordable, transparent, clinically relevant results

Heather McLaughlin, PhD, FACMG, Medical Director, Invitae
April 02, 2020
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In this webinar (for clinicians in the EMEA time zone), Heather McLaughlin, PhD, FACMG, will provide an in-depth discussion of the Invitae Boosted Exome, including patient selection, ordering tips, coverage performance, and how Invitae's rigorous analysis is informed by the patient's phenotype and genotype.


Invitae Boosted Exome: Providing affordable, transparent, clinically relevant results

Heather McLaughlin, PhD, FACMG, Medical Director, Invitae
March 12, 2020
View Recording

In this webinar, Heather McLaughlin, PhD, FACMG, will provide an in-depth discussion of the Invitae Boosted Exome, including patient selection, ordering tips, coverage performance, and how Invitae's rigorous analysis is informed by the patient's phenotype and genotype.


Integrating functional modeling to enhance clinical variant interpretation

Robert L. Nussbaum, MD (Invitae Chief Medical Officer) and Swaroop Aradhya, PhD, FACMG (Invitae Head of Global Medical Affairs)
March 03, 2020
View Recording

The webinar, intended for genetic counselors, geneticists, and other healthcare providers interested in variant classification, will help you understand how to:

* define the limitations of existing approaches to variant interpretation

* understand how to address variants of uncertain significance

* evaluate the validity and clinical application of robust, quantitative, and scalable functional modeling approaches to variant classification

Case examples will be provided. Participate in the Q&A session at the end of the webinar by asking questions during the webinar or submitting them in advance at the time of registration.


Diagnostic yield and precision medicine implications from genetic testing in epilepsy

Swaroop Aradhya, PhD, FACMG, Medical Director, Invitae; Molly Stetler, MS, CGC, Clinical Science Liaison, Invitae
January 28, 2020
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In this webinar, the speakers will examine the results of a large genetic epilepsy study conducted using the Invitae Epilepsy Panel to test more than 9,700 individuals. They will reinforce the need for early detection with genetic testing, discuss the potential precision medicine implications for patients, and highlight the benefits of our sponsored testing program for pediatric epilepsy.


Updated recommendations for the genetic evaluation of cardiomyopathy

Ray E. Hershberger, MD; Matteo Vatta, PhD; Ana Morales, MS, CGC
November 14, 2019
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In this webinar, guideline authors Ray E. Hershberger, MD, Matteo Vatta, PhD, and Ana Morales, MS, CGC, will review updated recommendations for the genetic evaluation of cardiomyopathy collaboratively published for the Heart Failure Society of America (HFSA) and the American College of Medical Genetics and Genomics (ACMG), including recommendations for family history, phenotype screening of at-risk family members, referral to expert centers, genetic counseling, and cardiovascular therapies.


Functional modeling: The next frontier in variant interpretation (Sponsored lunch session at the NSGC Annual Conference)

Brandie Heald Leach, MS, LGC, Cleveland Clinic; Carlos Araya, PhD, Invitae
November 07, 2019
View Recording

In this presentation, given as part of the NSGC Annual Conference in Salt Lake City, Genetic Counselor Brandie Leach discusses the complexity of variant interpretation and VUSs, and their impact on patients. Dr. Carlos Araya provides background information on Invitae's approach to variant interpretation using the Sherloc framework and discusses our efforts to enable high quality variant interpretation at scale. He then discusses the details of the functional modeling technology and its performance. Finally, he reviews future efforts at Invitae for scaling molecular and cellular evidence to improve variant classification at Invitae.


Invitae's sponsored testing programs

Michelle Fox (MS, LCGC), Michael Hamilton (Chief Privacy Officer), and Gautam Mehta (BioPharma Partnerships) (Invitae)
October 10, 2019
View Recording

Please join us on October 10 to learn from Michelle Fox and Michael Hamilton as they discuss how Invitae's sponsored testing programs are increasing access to genetic testing.

Michelle Fox provides consultation services to organizations, laboratories, and businesses, including Invitae. She is President of the Southern California Genetic Counselors and was recently elected to the National Society of Genetic Counselors Board of Directors.

Gautam R Mehta currently leads the Biopharma Implementation team at Invitae. As part of this team, he is working to scale and streamline the operations of all of Invitae's biopharma programs, which help reduce barriers to genetic testing and enable patients get an accurate diagnosis faster. Previously, Gautam led international lab operations and helped design and develop Invitae's assays and clinical lab workflows. Before joining Invitae, Gautam worked at Pfizer building next-generation sequencing assays to identify novel targets for drug development.

Michael Hamilton has extensive experience working with businesses to identify ways that healthcare and genetic data can be used in compliance with privacy laws to further scientific understanding and advancement. At Invitae, Michael works on a range of privacy and regulatory issues, with a focus on how genetics-related data can be used and shared.