Flexible follow-up testing

Invitae is dedicated to making sure your patients—and their families—have the answers they need. These are some additional testing options.

Re-requisition

If you don’t get the answers you need on your first panel test, expand to more genes at no additional charge.

Depending on your patient’s clinical and family history, it may be appropriate to begin with a targeted panel. If you don’t find the answers you’re looking for, you can broaden your search by ordering more genes within the original clinical area.

Invitae’s re-requisition service is offered at no additional charge for 150 days after your patient’s first report. (The timeline to place this order has been temporarily extended from 90 days.) No new specimen is required.

Family variant testing

If your patient is found to have a pathogenic or likely pathogenic variant, Invitae can test their family members for that gene.

All blood relatives of patients found to have a pathogenic or likely pathogenic variant on an Invitae diagnostic or proactive test are eligible for family variant testing. Our family variant testing reports on the variant(s) that was identified in the original family member, as well as any other pathogenic variant(s) found in the full gene.

VUS resolution

In some cases, Invitae may offer family testing to help resolve a variant of uncertain significance (VUS).

In order to help resolve variants of uncertain significance in Invitae panel test results, we offer follow-up testing at no additional charge to family members of patients previously tested at Invitae when the testing may clarify the relationship between the variant and the genetic condition. Not all variants can be resolved through this kind of analysis.

Although participation in this program may not result in an immediate reclassification of the VUS, the reclassification may still occur at a later date after multiple families with the variant are tested. If a variant is reclassified, Invitae will issue amended reports with the new interpretation to all individuals we’ve tested who have the variant.

Autosomal dominant Autosomal recessive X-linked; male proband X-linked; female proband
Most helpful

Both parents OR affected first-, second-, or third-degree relatives on the same side of the family

Both parents + 1 first-degree affected relative

Mother + affected male sibling or maternal relative

2 affected first-, second-, or third degree relatives on the same side of the family

Both parents Both parents Mother only Both parents
One parent Affected or unaffected siblings Mother + unaffected brother Unaffected brother(s) or son(s)
Unaffected siblings or children** Unaffected children
Affected second-degree relatives
Least helpful Unaffected second-degree relatives**