Genetic testing for hereditary breast cancer

Rapid genetic testing to inform surgical decisions

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Accessible genetic testing for breast cancer patients

Genetic information can be a powerful tool when treating patients with breast cancer. However, data suggest that many breast cancer patients with clinically actionable genetic variants are still being overlooked.1,2 In fact, the American Society of Breast Surgeons (ASBrS) now recommends genetic testing be made available to all patients with breast cancer.3 Invitae can help with high-quality, affordable genetic testing and a patient-pay price of $250. Start an order today >

85% of breast cancer patients who met clinical guidelines for genetic testing never received it—an estimated 800,000 women in the US.1

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Patients who do not meet clinical guidelines for genetic testing have positive rates nearly as high as patients who meet guidelines.2

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Benefits of testing

Genetic information impacts surgical decisions and future diagnoses

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Test options

Up-to-date clinical guideline criteria to help identify patients at risk

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Results

Understanding your patients’ results and next steps

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Invitae advantage

Fast, affordable, high-quality genetic testing you can count on

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Benefits of genetic testing

Genetic testing can uncover actionable findings, leading to a significant change in clinical management.

Cancer treatment

Rapid or STAT genetic test results can inform quick surgical decisions without disrupting treatment timelines. Genetic information may qualify patients for participation in clinical trials or research studies.

Future diagnoses

Increased surveillance can identify cancer at its earliest, most treatable stage. Risk-reducing surgery and/or chemoprevention can significantly decrease the chance of future cancers in the same or different organ systems.

Family members

Genetic information can benefit close relatives and allow for risk stratification. Relatives at high risk can undergo enhanced surveillance, while those without the family variant may be able to avoid unnecessary procedures.

Typical testing criteria for insurance coverage

If your patient—or one of their close blood relatives—has any of the following, most insurance providers will cover genetic testing:*

  • Early-onset breast cancer (age 45 or younger)
  • Triple-negative breast cancer at or before age 60
  • Male breast cancer
  • Multiple BRCA-associated cancers in the same person
  • A family history of ovarian, breast, pancreatic, melanoma, or prostate cancer
  • Breast or ovarian cancer and Ashkenazi Jewish ancestry
  • Ovarian cancer

Although the great majority of patients who select insurance billing already pay less than $100 out of pocket with Invitae, our simple out-of-pocket cost estimator can bring peace of mind.

For patients who do not meet their insurance company's testing criteria, we offer $250 patient-pay pricing.

Expert-curated, comprehensive hereditary breast cancer panels

Invitae Breast Cancer STAT Panel

A panel curated for breast surgeons with rapid results in 7 days, on average

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Invitae Common Hereditary Cancers Panel

A comprehensive cancer panel with results in 10-21 days, on average

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Not sure which panel is right for your patient?

Consult with one of our board-certified genetic counselors, available Monday through Friday, 5 am to 5 pm Pacific, to identify patients who could benefit from testing and differentiate between tests.

Ready to get started? Create an account today.

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What to do with your patients' results

positive

Positive result

Our board-certified genetic counselors are available to answer your questions about test results and even counsel your patients directly. Clinical consult >

Test blood relatives with Invitae’s family variant testing program. Learn more >

positive

Negative result

Expand to a larger hereditary cancer panel (if appropriate) within 90 days of receiving results, at no additional charge. View all cancer panels >

Our board-certified genetic counselors are available to answer your questions about test results and even counsel your patients directly. Clinical consult >

Informed families

Enable cancer prevention and early detection for your patient’s family members.

For patients who undergo panel or gene testing and are found to have a clinically actionable variant, their blood relatives can have up to a 50% risk of having the same variant.

Invitae offers family variant testing for all blood relatives of patients who undergo gene or panel testing at Invitae and have a positive result.

As an adult, Becky Carter discovered that she had a family history of breast cancer. "When I took the steps to do the testing, I was not fully aware of what the impact would be," she says. "I knew it would make me feel less fearful, but I did not expect the sense of empowerment that came from it."

Invitae advantage

STAT panels for time-sensitive breast cancer cases offer rapid results in 5–12 calendar days (7 days on average). Expand to a larger panel at no additional charge within 90 days.

Invitae testing is covered by most insurance plans, and we will not hold a sample or report while managing insurance claims.

Genetic counselors are available on demand to help identify patients who could benefit from testing, discuss tough cases, and even counsel your patients directly.

Get started

1. Request free kits for collecting patient specimens

2. Order a test using Invitae’s HIPAA-compliant online portal or on paper

  • Call Clinical Consult at 800-436-3037 if you would like to review patient cases or differentiate between testing options.

  • Patients can also contact Client Services for billing and insurance-related questions.

3. Receive an email when your results are ready (10-21 calendar days, on average)

  • If you have any questions about the results or their clinical implications, our genetic counselors are available to discuss.

Take the first step by requesting a free specimen collection kit or starting an order today.

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Tools for your clinic

Invitae’s reference guides offer direction on when to consider genetic testing and provide management guidelines. We have also created patient resources for you to share with your patients when speaking to them about genetic testing, like the video below.

Family history questionnaire

Collect your patient’s full family history to inform management

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Risks and references poster

Gene by gene risks for cancer, categorized by organ system

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Use this video to start the conversation about genetic testing with your patients.

Have a question or comment? Let us know.

Our team is here to answer your questions about ordering, billing, policies, and logistics as you are becoming familiar with our services.
 

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*These criteria have been adapted from current professional society guidelines. This is not an exhaustive list. Insurance criteria differ across providers. Patients who fit these criteria are not guaranteed to be covered by insurance for genetic testing.

References:

1. Childers CP et al. National estimates of genetic testing in women with a history of breast or ovarian cancer. J Clin Oncol. 2017;35(34):3800-6.
2. Beitsch P et al. Underdiagnosis of hereditary breast cancer: Are genetic testing guidelines a tool or an obstacle? J Clin Oncol. 2019;37(6):453-60. 
3. American Society of Breast Surgeons. Consensus guideline on genetic testing for hereditary breast cancer. Issued February 14, 2019.

Invitae is committed to delivering high-quality, affordable testing, with the goal of improving patients’ lives while also saving the healthcare system valuable dollars.

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