Discover Dysplasias™: New no-charge testing for individuals suspected of having a skeletal dysplasia. Learn more.
New: Sponsored, no-charge genetic testing and counseling for individuals diagnosed with pancreatic cancer. Learn more.
New: Reata and Invitae are offering a sponsored, no-charge genetic testing program for chronic kidney disease. Learn more.
Invitae prides itself on the quality of its gene curation. Our primary panels contain genes for which there is definitive evidence in the literature or from expert consensus that variants in these genes cause specific diseases. Preliminary-evidence genes are genes that are also selected from a review of the literature and expert recommendations, but are given the preliminary designation because currently there is only early evidence of a relationship between variants in these genes and specific diseases.
Some genes are designated preliminary-evidence because rare variants have been identified in patients, but these variants have not been proven to cause the disease. For others, the association between the gene and a specific disease has not been definitively established and additional studies are needed to strengthen the evidence. We highlight the difference between definitive-evidence and preliminary-evidence genes to help clinicians choose the most appropriate test for their patient.
Adding preliminary-evidence genes can increase the number of variants of uncertain significance (VUS), and can reveal pathogenic variants of uncertain relevance to the patient’s condition. However, this uncertainty may be resolved as new information becomes available, and some clinicians may wish to include these genes in their investigation.
Preliminary-evidence genes can be added by simply selecting the “opt-in” checkbox next to the list of genes.
With our flexible test options, clinicians can feel confident starting with only the genes they are comfortable with. Then, if they do not get the answers they need with their initial selection of genes, clinicians can submit a re-requisition for the analysis of additional genes within the original clinical area, at no additional charge.* We also offer clinical consultation services for clinicians who wish to discuss cases with genetic-counseling experts.
*Please see our Re-requisition web page for requirements and additional details.
Estimate your out-of-pocket cost for Invitae tests related to a personal or family history of breast, ovarian, colorectal, or uterine cancer.
The amount shown above is an estimate of your out-of-pocket cost based upon the information you entered about your health insurance coverage. It is not a confirmation that the test has been authorized by your insurance provider. Your final cost may vary based upon your health plan design, deductible, co-insurance, and out-of-pocket limits. Learn More >
As part of Invitae’s dedication to making high-quality genetic testing affordable and accessible, we also offer a patient pre-pay option of $250. Learn More >
We could not determine an out-of-pocket estimate. Please contact us for assistance.