• Test code: 81120
  • Preferred specimen:
    Formalin-fixed, paraffin-embedded (FFPE) tissue block with >1 cm3 of fetal tissue or 10 unstained FFPE slides at 7 microns thick and one H&E stained slide
  • Sample requirements
  • Request a sample kit

Invitae Pregnancy Loss Chromosomal Microarray Analysis for FFPE

Test description

Pregnancy loss chromosomal microarray analysis (CMA) analyzes products of conception (POC) tissue to determine whether a miscarriage, an intrauterine fetal demise (IUFD), or a stillbirth was caused by a chromosome abnormality.

  • Analyzes products of conception (POC) tissue that has been preserved in a formalin-fixed, paraffin-embedded (FFPE) block
  • Turnaround time is 10-12 days on average
  • Microarray analysis detects:
    • Whole and segmental aneuploidies
    • Submicroscopic gains and losses that cannot be detected using karyotype
    • Size and gene content of copy number variations (CNVs)
    • Regions of homozygosity, which may suggest shared ancestry and an increased risk for autosomal recessive disorders
    • Uniparental isodisomy, which can indicate a risk for an imprinting disorder
    • Triploidy and complete molar pregnancies
  • Simultaneously detects maternal cell contamination (MCC) without a maternal blood sample
  • Allows for appropriate medical management and recurrence risk counseling

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Invitae Pregnancy Loss Chromosomal Microarray Analysis for FFPE

Alternative tests to consider

Invitae also accepts fresh fetal or placental tissue, amniotic fluid (AF), chorionic villus sample (CVS), cultured amniocytes, and cultured chorionic villi. Select the test below to order this analysis for these sample types.