• Test code: 81110
  • Preferred specimen:
    Fresh fetal or placental tissue, amniotic fluid (AF), chorionic villus sample (CVS), cultured amniocytes (1 confluent T25 flask), cultured chorionic villi (1 confluent T25 flask)
  • Sample requirements
  • Request a sample kit

Invitae Pregnancy Loss Chromosomal Microarray Analysis

Test description

Chromosomal microarray analysis (CMA) for pregnancy loss analyzes products of conception (POC) to determine whether a miscarriage, an intrauterine fetal demise (IUFD), or a stillbirth was caused by a chromosome abnormality.

  • Turnaround time is 10-12 days on average
  • No cell culture required
  • Microarray analysis detects:
    • Whole and segmental aneuploidies
    • Submicroscopic gains and losses that cannot be detected using karyotype
    • Size and gene content of copy number variations (CNVs)
    • Regions of homozygosity, which may suggest shared ancestry and an increased risk for autosomal recessive disorders
    • Uniparental isodisomy, which can indicate a risk for an imprinting disorder
    • Triploidy and complete molar pregnancies
  • Simultaneously detects maternal cell contamination (MCC) without a maternal blood sample
  • Allows for appropriate medical management and recurrence risk counseling

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Invitae Pregnancy Loss Chromosomal Microarray Analysis

Alternative tests to consider

In cases where collecting a fresh tissue sample is not an option, Invitae accepts formalin-fixed, paraffin-embedded (FFPE) samples.