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Invitae Twin NIPS (chromosomes 13, 18, 21)

Test description

Invitae Twin Non-invasive Prenatal Screening (NIPS) analyzes whether a twin pregnancy is at increased risk for the chromosome disorders listed below.

All NIPS reports include analysis of chromosomes 21, 18, and 13 and assess the risk of the following trisomies:

  • Trisomy 21 (Down syndrome)
  • Trisomy 18 (Edwards syndrome)
  • Trisomy 13 (Patau syndrome)

Y chromosome analysis can also be included to determine if at least one twin is male. However, the presence of the Y chromosome cannot differentiate between one male twin or two male twins. To include Y chromosome analysis in your order, please select the checkbox below.

Please see the Disorders Tested section for more information about these chromosome disorders.

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Invitae Twin NIPS (chromosomes 13, 18, 21)
Add-on Y Chromosome (to predict fetal sex)

Analysis of the presence of the Y chromosome can be added at no additional charge.

Alternative tests to consider

DisorderChromosomeDescriptionPrevalence
Down syndrome Trisomy 21 Although some pregnancies with trisomy 21 end in pregnancy loss, trisomy 21 often can lead to live birth. Individuals with trisomy 21 have variable physical features and intellectual disability. Some of the common features of trisomy 21 include heart defects, low muscle tone, and differences in facial features. In addition, cognitive impairment can range from mild to severe. People with Down syndrome have a higher risk for certain medical conditions, such as hearing problems, thyroid problems, childhood leukemia, and Alzheimer’s disease. People with Down syndrome may require supervision throughout their lives. However, many people with Down syndrome are increasingly attending school and holding jobs. Many individuals with Down syndrome live into adulthood. Trisomy 21 is the most common chromosome abnormality, occurring in 1 in 700 to 800 live births.
Edwards syndrome Trisomy 18 Although many pregnancies with trisomy 18 result in miscarriage or stillbirth, trisomy 18 can result in livebirth. Individuals with trisomy 18 have severe intellectual disability and abnormalities involving multiple organs. Some of the common fea-tures of trisomy 18 include heart defects, brain abnormalities, muscu-loskeletal problems, cleft lip and palate, and low birth weight. Although less than 10% of babies with trisomy 18 will live past 1 year of age, some people with this condition can live years or even decades. Trisomy 18 occurs in 1 in 6000 to 8000 live births.
Patau syndrome Trisomy 13 Although the majority of pregnancies with trisomy 13 result in miscarriage or stillbirth, trisomy 13 can result in live birth. Individuals with trisomy 13 have severe intellectual disability and abnormalities involving multiple organs. Some of the common features of trisomy 13 include heart defects, omphalocele, brain abnormalities such as holoprosencephaly, cleft lip and palate, and other features. Although less than 10% of babies with trisomy 13 will live past 1 year of age, some people with this condition can live years or even decades. Trisomy 13 occurs in approximately 1 in 12,000 live births.
Gene Transcript reference Sequencing analysis Deletion/Duplication analysis
Chromosome 13
Chromosome 18
Chromosome 21
Chromosome Y