ECHA; GBP; HADH; LCEH; LCHAD; MTPA; TP-ALPHA
The HADHA gene is associated with autosomal recessive long chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency (MedGen UID: 442134) and autosomal recessive mitochondrial trifunctional protein deficiency (MedGen UID: 87460).
Order this gene as a single gene test.
Invitae tests that include this gene:
An estimated 68% of trifunctional protein deficiency cases are due to pathogenic variants in the HADHA gene (PMID: 21549624). Pathogenic variants in HADHA are the only known cause of Long Chain 3-hydroxyacyl-CoA dehydrogenase deficiency (PMID: 20814823).
The HADHA gene encodes the alpha-subunit harboring long-chain enoyl-CoA hydratase and longchain L-3-hydroxyacyl-CoA dehydrogenase of the mitochondrial trifunctional protein (TFP) multienzyme complex which catalyses fatty acid beta oxidation cycle (PMID: 1550553).
Invitae is a College of American Pathologists (CAP)-accredited and Clinical Laboratory Improvement Amendments (CLIA)-certified clinical diagnostic laboratory performing full-gene sequencing and deletion/duplication analysis using next-generation sequencing technology (NGS).
Our sequence analysis covers clinically important regions of each gene, including coding exons, +/- 10 base pairs of adjacent intronic sequence in the transcript listed below. In addition, analysis covers the select non-coding variants specifically defined in the table below. Any variants that fall outside these regions are not analyzed. Any specific limitations in the analysis of these genes are also listed in the table below.
Our analysis detects most intragenic deletions and duplications at single exon resolution. However, in rare situations, single-exon copy number events may not be analyzed due to inherent sequence properties or isolated reduction in data quality. If you are requesting the detection of a specific single-exon copy number variation, please contact Client Services before placing your order.
|Gene||Transcript reference||Sequencing analysis||Deletion/Duplication analysis|