Sponsored, no-charge genetic testing brought to you by Invitae and Calcilytix Therapeutics Inc., for individuals with an established diagnosis of non-surgical hypoparathyroidism

An established diagnosis of non-surgical hypoparathyroidism may have an impact on clinical management of the condition:

  • Hypoparathyroidism is estimated to affect ~70-80K individuals in the US. The primary cause of hypoparathyroidism is due to radical neck surgery, however there are non-surgical causes that can include the inheritance of certain genes.
  • Hypoparathyroidism can cause low levels of blood calcium (hypocalcemia) and elevated levels of calcium excreted in the urine (hypercalciuria). Prolonged parathyroid disease can lead to other health issues that may result in serious complications. 
  • Symptoms of hypoparathyroidism can include hypocalcemia-related neuromuscular (i.e. cramps, paresthesia, and/or seizures), cardiovascular, and neurological (i.e. fatigue and/or cognitive impairment) manifestations. 

About the Hypoparathyroidism Genetic Testing program


The Hypoparathyroidism Genetic Testing program is a sponsored, no-charge genetic testing and counseling program for patients with an established diagnosis of non-surgical hypoparathyroidism. The Hypoparathyroidism Genetic Testing program is intended to build knowledge about the genetic causes of hypoparathyroidism and support clinical management so that individuals and their providers can make more informed decisions about their health. A few notes about this program:

  • While Calcilytix provides financial support for this program, tests and services are performed by independent third parties.
  • Healthcare professionals must confirm that patients meet certain criteria to use the program.
  • Calcilytix receives de-identified patient data from this program, but at no time will Calcilytix receive patient-identifiable information. 
  • Calcilytix uses the de-identified patient data for research and commercial purposes, including:
    • Improving the understanding of hypoparathyroidism epidemiology and clinical presentation
    • Understanding the burden of illness for genetic causes of hypoparathyroidism vs. non-genetic hypoparathyroidism
    • Identifying potential clinical trial candidates through their providers
  • The Hypoparathyroidism Genetic Testing program is only available to patients and their providers in the US. 
  • Healthcare professionals or patients who use this program have no obligation to recommend, purchase, order, prescribe, promote, administer, use, or support any Calcilytix product.

Program eligibility

This program is available to individuals in the US with an established diagnosis of non-surgical hypoparathyroidism (low or no parathyroid hormone) or to individuals who have a first-degree relative with an established diagnosis of genetic hypoparathyroidism.     

Genetic testing with Invitae

The Hypoparathyroidism program offers testing with the Invitae Hypoparathyroidism and Hyperparathyroidism Panel, which analyzes genes associated with various hereditary causes of parathyroid disorder.


How to order

1. Submit an order

To place your online order, click here and follow the on-screen prompts.

To place a paper-based order, download the paper order form and include it in the specimen box. 

2. Collect a specimen

If a specimen collection kit was not ordered during the online ordering workflow, order a blood, buccal, or saliva collection kit here
Please view specimen and shipping requirements for important information, and be sure to include the completed requisition form in the kit with the specimen. 

3. Receive results

On average, results are available 10-21 days after Invitae receives the specimen. You will receive a notification email once the test results are ready.
Log in to view the status of your online order. 

Next steps and additional services

Broaden your search with re-requisition

If you don’t find answers with your initial order, 
Hypoparathyroidism Genetic Testing Program includes one re-requisition within 90 days to re-test genes within the original clinical area.

Simply log into your account, navigate to the order, and click "Add rerequisition”

Family variant testing for familial insights

If a positive result is identified, testing for your patient’s family members is available.

Simply follow the ordering instructions, selecting only the gene(s) you are interested in testing for the family member.

Support every step of the way

Client Services

Available to answer your questions or help you through the testing process.

Clinical Support Services

Licensed, board-certified genetic counselors, ready to support you.

About Invitae

Invitae Corporation (NYSE: NVTA) is a leading medical genetics company, whose mission is to bring comprehensive genetic information into mainstream medicine to improve healthcare for billions of people. Invitae's goal is to aggregate the world's genetic tests into a single service with higher quality, faster turnaround time, and lower prices. For more information, visit the company's website.

About Calcilytix

Calcilytix is a clinical-stage biopharmaceutical company focused on developing a targeted therapy for disorders of calcium homeostasis. Calcilytix's product candidate, encaleret, is an investigational orally-administered small molecule designed to inhibit the calcium-sensing receptor, hypothesized to restore normal serum calcium and urine calcium.

Calcilytix is led by a team of industry veterans who have been responsible for developing over 30 molecules through Initial New Drug (IND) applications and more than 10 approved drugs. Together with physicians and patients, Calcilytix aims to develop a safe and effective treatment option for patients with hypoparathyroidism and autosomal dominant hypocalcemia type 1 (ADH1).