BRCA1 and BRCA2 are genes that produce proteins involved in DNA repair. When either of these genes is altered or mutated, DNA repair may not progress correctly. This can lead to the development of certain types of cancer. BRCA mutations can be hereditary (germline) or occur spontaneously (sporadic).1,2
People with DNA repair deficiencies such as a germline BRCA mutation are significantly more likely to develop early onset of breast cancer and have a high risk to have recurrence in the contralateral breast at a later stage.
gBRCA mutations account for:
● ~3-6% of all Breast Cancers4-6
● ~4-16% of Male Breast Cancers7
● ~25% of Hereditary Breast Cancers8,9
In addition to the informing treatment decisions in patients with HER2- LA/mBC, knowing the status of the BRCA1 and BRCA2 genes may allow patients to inform family members of their potential risk.
NCCN Clinical Practice Guidelines In Oncology (NCCN Guidelines®):
In the metastatic setting, results from genetic testing may have therapeutic implications. Germline mutations in BRCA1 and BRCA2 have proven clinical utility and therapeutic impact.
Therefore, germline BRCA1 and BRCA2 should be assessed in all patients with recurrent or metastatic breast cancer to identify candidates for poly adenosine diphosphate ribose polymerase (PARP)-inhibitor therapy.10
The BRCA Care genetic testing program sponsored by Pfizer is available to patients with HER2-negative locally advanced or metastatic breast cancer (HER2- LA/mBC) in the following countries:
United Arab Emirates
Asia Pacific (Hong Kong, Singapore, Taiwan)
To order test kits please email firstname.lastname@example.org and reference the BRCA Care program in the email.
Latin America (Chile)
To order test kits please email email@example.com and reference the BRCA Care program in the email.
Middle East (Lebanon, Oman, Qatar, Saudi Arabia, United Arab Emirates)
To order test kits please visit www.invitae.com/request-a-kit or email firstname.lastname@example.org and reference the BRCA Care program in the email.
The BRCA Care program offers testing with the Invitae BRCA1 and BRCA2 STAT Panel, which analyzes the BRCA1 and BRCA2 genes.
Once Invitae receives your patient’s blood or saliva specimen, their results will be available in 5 to 12 calendar days (7 days on average). Accelerated turnaround time may be necessary because physicians and patients often want to make management decisions as quickly as possible.
The BRCA Care program offers clinicians the ability to receive subsequent analysis by re-requisition to a larger cancer panel. For example, the Invitae Multi-Cancer Panel which includes 84 genes associated with hereditary cancers across major organ systems.
This subsequent analysis is offered at no additional charge if ordered within 90 days of the original report release. No new sample is required.
Invitae’s team of board-certified and experienced genetic counselors trained in medical genetics is available to assist clinicians. Clinicians can reach our genetic counselors by calling +1 (415) 930-4018 , Monday through Friday, 5:00 am to 5:00 pm Pacific Time.Contact
Invitae will also offer family variant testing (FVT) for all blood relatives of patients found to have a pathogenic or likely pathogenic variant, at no additional charge within 90 days of the original patient’s test. Our family variant testing reports on the presence or absence of the familial variant(s) as well as any clinically informative variants in the full gene.
Invitae is a genetic information company whose mission is to bring genetic information into mainstream medical practice to improve the quality of healthcare for billions of people. Specializing in genetic diagnostics for hereditary disorders, Invitae is aggregating the world’s genetic tests into a single service with better quality, faster turnaround time, and a lower price than most single-gene tests today.
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While Pfizer may provide financial support for this program, tests and services are performed by Invitae. Healthcare professionals must confirm that patients meet certain criteria to use the program. Pfizer may receive de-identified patient data from this program, but at no time would they receive patient identifiable information. Pfizer may receive contact information for healthcare professionals who use this program. Healthcare professionals and patients who participate in this program have no obligation to recommend, purchase, order, prescribe, promote, administer, use or support any other products or services from Invitae or from Pfizer.